Schalke 04, Lokomotiv Moscow and Stoke City sealed places in the last 32 of the Europa League but a 2-0 defeat at Salzburg left Paris St Germain coach Antoine Kombouare looking over his shoulder on Thursday.
Tottenham Hotspur exposed the weaknesses in Anzhi Makhachkala's star-shorn squad, winning 2-0 in Moscow to maintain their perfect start in the second round of Europa League group stage matches on Thursday.
Anderlecht kept up their 100 percent record in the Europa League with a 2-0 win at Sturm Graz while Udinese struck late to sink Atletico Madrid by the same score in Thursday's top match.
Sevilla's love affair with the Europa League was immediately rekindled as last season's champions and three-time winners began this year's group stage with a 2-0 home victory over Feyenoord on Thursday.
Seven-time European champions AC Milan will face Arsenal in the standout last-16 tie in the Europa League after the draw was made in Nyon, Switzerland on Friday.
Atletico Madrid striker Antoine Griezmann struck twice as the Spanish side outclassed hapless Olympique de Marseille 3-0 on Wednesday to win the Europa League for the third time.
UEFA Cup holders Shakhtar Donetsk thrashed Club Bruges 4-1 away on Thursday when top-level football began experimenting with five-man refereeing teams in the opening Europa League group stage games.
The attractive football preached by Swansea City manager Michael Laudrup was displayed to great effect when the Welsh side stunned 10-man Valencia with a 3-0 away victory in the Europa League.
Jonathan Soriano scored an incredible goal from near the halfway line to complete a stunning 3-0 win for Salzburg away to once-mighty Ajax Amsterdam in the Europa League round of 32 on Thursday.
Juergen Klopp, who has breathed new life into Liverpool in his seven months in charge, would seal his place in the hearts of the club's supporters if he pulls off victory over Sevilla in Wednesday's Europa League final.
PSV Eindhoven's disappointing season took a turn for the worse as they went out of the Europa League after losing 1-0 at home to Ukrainians Chernomorets Odessa, who pipped them to second place in Group B on Thursday.
Manchester United's hopes of salvaging their season in the Europa League suffered a stinging setback when they lost 2-1 at Danish side Midtjylland in the first leg of their last-32 clash on Thursday.
Tottenham Hotspur's Europa League hopes were crushed by mid-table Belgian side Gent, who booked their spot in the last 16 with a 2-2 draw at Wembley on Thursday as the hosts paid the penalty for Dele Alli's first-half red card.
Liverpool added another fairytale comeback to the history books as they fought back from 3-1 down against Borussia Dortmund to reach the Europa League semi-finals after Dejan Lovren's towering stoppage-time header secured a 4-3 win on Thursday.
Arsenal and Chelsea were among seven teams to reach the Europa League knockout stage on Thursday, while last year's runners-up Olympique de Marseille were eliminated at the group phase.
Estoril's home Europa League clash with PSV Eindhoven was suspended at halftime on Thursday due to adverse weather and will be finished on Friday, UEFA said.
Three time European champions Inter Milan were stunned 2-0 at home by Israeli side Hapoel Beer-Sheva and Manchester United were floored by a late goal from Feyenoord as the Europa League group stage got underway on Thursday.
Eintracht Frankfurt won the Europa League final after holding their nerve to beat Rangers 5-4 in a clinical penalty shootout as they claimed their first European trophy in 42 years.
Fiorentina tore apart Italian rivals AS Roma to reach the Europa League quarter-finals with a 3-0 win that left their opponents' season in tatters and under-fire coach Rudi Garcia tottering on the brink of the sack.
IMAGES from the Europa League semifinal played between Manchester United and Sevilla in Cologne on Sunday.
Emmanuel Adebayor scored twice in four minutes as Tottenham Hotspur overturned a two-goal aggregate deficit to beat 10-man Dnipro Dnipropetrovsk 3-2 over two legs on Thursday to reach the last 16 of the Europa League.
Holders Porto crashed out of the Europa League after a 4-0 thumping at Manchester City completed a 6-1 aggregate win for the English Premier League leaders on Wednesday.
Villarreal's Adrian Lopez produced a stinging sucker punch in stoppage time to leave Liverpool reeling and move the Spaniards closer to a maiden European final after their Europa League last four first leg clash finished 1-0 on Thursday.
Napoli began their Europa League group stage campaign in scintillating fashion.
The much-maligned Europa League threw up a bumper mix of goals, controversy and defensive blunders on Thursday as Chelsea, Benfica and Fenerbahce won by two-goal margins at home and Basel held Tottenham Hotspur.
Sevilla coach Unai Emery has been picking the brains of Juande Ramos as he tries to plot the downfall of Ukrainian outsiders Dnipro Dnipropetrovsk in Wednesday's Europa League final.
Juventus were astonishingly held to a 3-3 home draw by Lech Poznan as the Europa League group stage kicked off on Thursday while holders Atletico Madrid began the defence of their crown with a 1-0 defeat at Aris Salonika.
Sevilla, winners of the Europa League for the past two years, will play Shakhtar Donetsk in this season's semi-final.
Manchester United scraped into the last 16 of the Europa League on Thursday, narrowly avoiding a humiliating elimination after being outplayed and losing 2-1 at home to Ajax Amsterdam.
Kazakhstan's Astana fought back to beat a youthful Manchester United side 2-1 at home, Arsenal's woes continued as Frankfurt's Daichi Kamada scored twice to secure a 2-1 win.
Diego Forlan and Sergio Aguero proved too classy a double act for Fulham in Wednesday's Europa League final, the two South Americans combining to earn Atletico Madrid a 2-1 win and a first major European trophy in 38 years.
Liverpool manager Juergen Klopp enjoyed a satisfying return to Borussia Dortmund as his new side frustrated his former charges and claimed a valuable away goal to draw 1-1 in their Europa League quarter-final, first leg on Thursday.
New Schalke 04 coach Huub Stevens rekindled memories of leading the Germans to 1997 UEFA Cup glory with an easy 3-1 win over Maccabi Haifa in the second round of Europa League group matches on Thursday but favourites Paris St Germain lost.
Arsenal's young guns continued to shine as they dismantled Standard Liege 4-0 on a hectic night of Europa League action that produced a full house of Spanish victories on Thursday. A summary of the matches.
Manchester United flirted with calamity before coasting into the Europa League last 16 as debutant Marcus Rashford helped them overcome an early blow with two goals in a 5-1 home victory over Midtjylland on Thursday.
Mouth-watering matches lined up as PSG to face Bayern and Barcelona in Champions League opening stage.
Chelsea beat Eintracht Frankfurt on penalties on Thursday to set up an all-English Europa League final with local rivals Arsenal in Baku on May 29.
Napoli's Marek Hamsik enjoyed a memorable return to his former club Slovan Bratislava, scoring one and creating another, in a 2-0 victory on Thursday as the Italians joined five others who made it two wins from two in the Europa League group stage.
Arsene Wenger praised his Arsenal players for the 'resilient and disciplined' way in which they qualified for the Europa League quarter-finals with a 3-1 win over AC Milan on Thursday.
IMAGES from the Europa League matches played on Thursday